1 in every
1,900 babies born in the UK
have sickle cell disease

Great Angels Foundation
  • Sickle Cell Anaemia (SCA) is the most common of the sickle cell diseases and is defined by the presence of the abnormal haemoglobin HbS.

  • This is caused by having two copies of the beta-globin gene containing the genetic alteration for HbS.

  • The other forms of sickle cell disease result from inheriting a genetic alteration for HbS in one gene and another abnormal beta-globin chain variant in the second beta-globin gene.

Always on your terms

What we do

We provide support to people affected by sickle cell disease to enable them live normal life.

Get involved

Campaign, volunteer, fundraise, donate - get involved and promote awareness of sickle cell disease.

What is sickle cell

Sickle cell disease is a blood disorder that's inherited from parents to their children.

What You Need to Know

Sickle cell anaemia is a disease passed down through families. It is an inherited condition of the blood and it is considered the most common genetic disease. It is a group of disorders that affects haemoglobin. Haemoglobin is the protein, which carries oxygen to the tissues.

Not contagious

Sickle cell disease is not contagious, but is acquired at birth. It occurs when a child inherits two sickle haemoglobin genes, one from each parent. 

Caused by a genetic abnormality

The disease is caused by a genetic abnormality in the gene for haemoglobin, which results in the production of sickle haemoglobin.

Improved life expectancy

Life expectancy for patients with Hb-SS has increased to a median of 45 years and for HbSC patients to 65 years, a significant improvement from 14.3 years for Hb-SS 3 patients.